摘要
目的研究白屈菜红碱明胶微球的制备工艺,并考察其体外释放特性。方法用可生物降解的明胶为载体,液体石蜡为油相,Span 80为乳化剂,采用正交设计优化制备工艺,用乳化交联法制备白屈菜红碱明胶微球。结果优选所制的白屈菜红碱明胶微球形态圆整,粒径在10～40μm范围内者占总数的81.86%,载药量为0.65%,包封率为72.42%。21h体外释放51.49%,75h释放达94.33%。结论优化后的白屈菜红碱明胶微球工艺简单,包封率高,制得白屈菜红碱明胶微球具有良好的缓释效果。
Objective To study the preparation technology and its release characteristics in vitro.Methods Gelatin microspheres loaded chelerythrine were prepared by a emulsion crosslinking method,and the preparation technology was optimized by an orthogonal experimental design with biodegradable gelatin as the carrier,liquid paraffin as the oil phase,span 80 as the emulsifier.Results The optimal gelatin microspheres loaded chelerythrine were global.The size of 81.86% microspheres were in the range of 10-40 μm,0.65% for the drug loading,72.42% for the encapsulation efficiency.The release test in vitro showed that 51.49% of chelerythrine could release from gelatin microspheres in 21 hours and 94.33% in 75 hours.Conclusion The preparation technology is simple,and with high encapsulation efficiency.The obtained microspheres can control the release of chelerythrine.
出处
《西北药学杂志》
CAS
2013年第2期191-194,共4页
Northwest Pharmaceutical Journal
关键词
白屈菜红碱
明胶
正交设计
微球
chelerythrine
gelatin
microspheres
orthogonal experimental design
