海洋链霉菌S09的化学成分研究

Chemical Constituents from Marine Streptomycete sp.S09

从海洋链霉菌S09的发酵液提取物中分离得到6个化合物,通过波谱技术分别鉴定为:thymidine(1)、尿嘧啶(2)、3-甲基-2,5-哌嗪二酮(3)、2-吡咯甲酸(4)、卡拉霉素(5)和β-咔啉(6)。海虾致死实验结果显示:化合物5在10μg/mL的浓度下对丰年虾的致死率为87.6%,显示出较强的细胞毒活性。

Six compounds were isolated from the fermented broth extract of the marine Streptomycete sp. S09. Their structures were identified as thymidine （ 1）, uracil （2）, 3-methyl-2,5-piperazinedione （3）, pyrrole-2-carboxylic acid （4）, clarithromycin （5） and β-carboline （6） by spectral methods. The cytotoxic activities of the 6 compounds were tested by the brine shrimp bioassay. The mortality rate of brine shrimp was 87.6% for clarithromycin （5） at the concentration of 10 μg/mL. It indicated that clarithromycin （5） had significant toxicity on brine shrimp.