青年与中老年结直肠癌临床及病理资料对比分析

Comparison on the Clinical and Pathological Data of Colorectal Carcinoma in Youths and in Middle and Old age

为比较青年与中老年结直肠癌临床及病理特征，回顾2002年12月至2009年6月我院收治的420例结直肠癌患者资料，将其分为青年（≤40岁）组（50例）和中老年（〉40岁）组（370例）进行对比分析。结果显示，两组患者性别构成、肠梗阻发生率、治疗方法方面差异均无统计学意义，P〉O．05；但在有无家族史、疼痛出血发生率、病程、误诊情况、肿瘤部位、肠镜分型、组织学分型、Dukes分期、预后方面，两组差异均有统计学意义，Pd0．05。结果表明，与中老年结直肠癌患者相比，青年结直肠癌患者有家族史者多，好发于直肠，以浸润性生长为主，分化程度低，临床分期高，误诊率高，预后差。临床上应提高对青年结直肠癌患者的警惕性，早期诊断，争取行根治性手术。

In order to compare the clinical and pathological features of colorectal carcinoma in youths and in middle and old age, author retrospectively analyzed the data of 420 colorectal cancer patients admitted in author＇s hospital（2002-12--2009-06）,divided them into youth group（age 〈40yr. , n =50） and middle and old age group（40yr. , n 370） and compared with each other. As results,in sex component,incidence of intestinal obstruction and treatment methods there was no statistical differences between two groups（ P 0.05）, but in with or without familial history, incidence of pain and bleeding, disease course, misdiagnosis status, neoplasms site, enteroscopy typing, histological typing, Duke＇s staging, and prognosis, etc, there all was statistical differences（ P 〈0.05）. Results show that compared with middle and old age group youth patients mostly have familial history, are liable to occur in rectum, predominanted by infiltration growth, lower differentiation, higher clinical stage, higher misdiagnosis rate as well worse prognosis, thus clinically it should be to pay more attention to youth＇s colorectal cancer,and to diagnose it early,to take radical oper ation possibly.