小麦纤维素联合莫沙比利口服治疗慢传输型便秘的临床疗效

Oral Administration of Wheat Cellulose and Mosapride in the Treatment of Slow Transit Constipation

为探讨小麦纤维素联合莫沙比利口服治疗慢传输型便秘（sTc）的临床疗效，将150例STC随机分为治疗组和对照组，各75例，治疗组予小麦纤维素联合莫沙比利口服，对照组单纯给予莫沙比利口服，对比两组临床疗效及复发情况。结果显示，（1）临床疗效：治疗4周后，治疗组临床痊愈27例，显效31例，有效12例，无效5例，总有效率为93．3％（70／75）；对照组临床痊愈9例，显效15例，有效28例，无效23例，总有效率为69．3％（52／75）。治疗组总有效率明显高于对照组，P〈0．05。（2）复发情况：对有效者随访6个月，治疗组复发率为25．7％（18／70），对照组复发率为67．3％（35／52）。治疗组复发率明显低于对照组，P〈0．05。结果表明，小麦纤维素联合莫沙比利口服治疗STC疗效肯定，服用方便，无腹痛、腹泻及药物性依赖等副作用，患者易接受，而且复发率低，可作为STC的首选治疗方案。

The objective of this study was to investigate the clinical effect of oral administration of wheat cellulose and mosapride for teating slow transit constipation（STC）. The 150 cases of STC were randomly divided into treatment group and contrl group, 75 cases for eachtreatment group received oral wheat cellu- lose plus mosapride,while control group alone oral mosapride,then the clinical effect and recurrence status were compared between both groups. As results, 1） clinical effect, after treatment lasted 4 weeks in treat- ment group, 27 cases were cured, 31, excellent response, 12 effective, 5 non-response, and total effective rate was 93.3^（70/75） ,meanwhile,in control group,9,15,28,23,and 69.3^（52/75） respectively,thus the to- tal effective rate of treatment group was significantly higher than that of control group（ P d0.05）~2）re- currence status：a follow-up lasted 6 months to the effective case showed that recurrecue rate of treatment group was significantly lower than that of control group（18/70,25.7% vs 35/52,67.3% P 〈0.05）. Re- sults show that oral administration of wheat cellulose plus mosapride in the treatment of STC has following merits：certain curative effect, conventionally to use, no adverse reactions as abdominal pain, diarrhea and substance dependence,etc,as well as low recurrence rate,patients being liable to use it,thus this combina- tion for treating STC could be as the first choice.