摘要
[目的]系统评价诱导型一氧化氮合酶(iNOS)在鼻咽癌(NPC)组织中的表达及其临床意义。[方法]电子检索Pubmed、Embase、Cochrane、CBM、CNKI、VIP和万方数据库,收集有关iNOS在鼻咽癌组织中的表达及其与临床特征关系的病例对照研究。用Stata9.2统计软件包进行Meta分析。[结果]共纳入病例对照研究8篇,合计研究对象502例。Meta分析结果显示,iNOS在鼻咽癌组织的表达高于正常鼻咽黏膜组织(OR=27.42,95%CI:13.51~55.64);在鼻咽癌组织中,有淋巴结转移者的iNOS表达高于无淋巴结转移者(OR=2.39,95%CI:1.33~4.30),低T分期者的iNOS表达低于高T分期者(OR=0.30,95%CI:0.14~0.64);而在不同年龄及性别中iNOS的表达差异无统计学意义。[结论]iNOS在鼻咽癌组织中呈高表达,并与淋巴结转移和T分期关联密切,提示其过度表达与鼻咽癌的发生、发展、浸润和转移密切相关。
[Purpose] To investigate the expression of inducible nitric oxide synthase(iNOS) in nasopharyngeal carcinoma(NPC) tissues and its clinical significance.[Methods] Case-control studies of the expression of iNOS in nasopharyngeal carcinoma tissues were searched from Pubmed,Embase,Cochrane,CBM,CNKI,VIP and WanFang databases.Meta-analysis was done using STATA 9.2.[Results] A total of 8 papers with 502 cases were included.Meta-analysis showed that as the positive rate of iNOS expression,significant difference was found between the NPC tissues and the control tissues(OR=27.42,95%CI:13.51~55.64).Higher expression was detected in NPC tissues with lymph node metastasis group than that in NPC tissues without lymph node metastasis group(OR=2.39,95%CI:1.33~4.30),while higher expression was detected in high T group than that in low T group(OR=0.30,95%CI:0.14~0.64),but no significance difference was found for age and sex.[Conclusion] NPC tissue has high iNOS expression,and it strongly relates to the lymph node metastasis and T staging.The over expression of iNOS may be relative to the carcinogenesis,progress,invasion and metastasis of NPC.
出处
《肿瘤学杂志》
CAS
2013年第3期166-170,共5页
Journal of Chinese Oncology
关键词
诱导型一氧化氮合酶
META分析
鼻咽肿瘤
inducible nitric oxide synthase
Meta-analysis
nasopharyngeal neoplasms