诱导型一氧化氮合酶在鼻咽癌中表达及意义的Meta分析

Expression of Inducible Nitric Oxide Synthase in Nasopharyngeal Carcinoma and Its Significance:A Meta-analysis

[目的]系统评价诱导型一氧化氮合酶(iNOS)在鼻咽癌(NPC)组织中的表达及其临床意义。[方法]电子检索Pubmed、Embase、Cochrane、CBM、CNKI、VIP和万方数据库,收集有关iNOS在鼻咽癌组织中的表达及其与临床特征关系的病例对照研究。用Stata9.2统计软件包进行Meta分析。[结果]共纳入病例对照研究8篇,合计研究对象502例。Meta分析结果显示,iNOS在鼻咽癌组织的表达高于正常鼻咽黏膜组织(OR=27.42,95%CI:13.51～55.64);在鼻咽癌组织中,有淋巴结转移者的iNOS表达高于无淋巴结转移者(OR=2.39,95%CI:1.33～4.30),低T分期者的iNOS表达低于高T分期者(OR=0.30,95%CI:0.14～0.64);而在不同年龄及性别中iNOS的表达差异无统计学意义。[结论]iNOS在鼻咽癌组织中呈高表达,并与淋巴结转移和T分期关联密切,提示其过度表达与鼻咽癌的发生、发展、浸润和转移密切相关。

[Purpose] To investigate the expression of inducible nitric oxide synthase（iNOS） in nasopharyngeal carcinoma（NPC） tissues and its clinical significance.[Methods] Case-control studies of the expression of iNOS in nasopharyngeal carcinoma tissues were searched from Pubmed,Embase,Cochrane,CBM,CNKI,VIP and WanFang databases.Meta-analysis was done using STATA 9.2.[Results] A total of 8 papers with 502 cases were included.Meta-analysis showed that as the positive rate of iNOS expression,significant difference was found between the NPC tissues and the control tissues（OR=27.42,95%CI：13.51～55.64）.Higher expression was detected in NPC tissues with lymph node metastasis group than that in NPC tissues without lymph node metastasis group（OR=2.39,95%CI：1.33～4.30）,while higher expression was detected in high T group than that in low T group（OR=0.30,95%CI：0.14～0.64）,but no significance difference was found for age and sex.[Conclusion] NPC tissue has high iNOS expression,and it strongly relates to the lymph node metastasis and T staging.The over expression of iNOS may be relative to the carcinogenesis,progress,invasion and metastasis of NPC.