子宫颈先天性移行区临床病理特点

Clinicopathologic analysis of congenital transformation zone of cervix

目的探讨子宫颈先天性移行区的临床病理特点。方法收集50例子宫颈先天性移行区病理标本,进行HE染色,显微镜观察,并复习临床病理资料。结果 50例子宫颈先天性移行区鳞状上皮有不同程度的角化不全或角化过度,上皮脚呈不规则的锯齿状向间质内延伸,部分上皮脚出现不同程度的角化,并可出现角化珠。细胞核较大,具有轻度的多形性,大部分呈圆形、卵圆形,核仁明显,核分裂象罕见。结论子宫颈先天性移行区常见鳞状上皮化生,常易被误认为病毒感染性疣,有时被误诊为子宫颈上皮内瘤变或浸润性鳞状细胞癌,准确认识子宫颈先天性移行区的病理特点有利于减少子宫颈疾病的误诊误治。

Objective To explore the clinical pathological features of congenital transformation zone （CTZ）. Methods Fifty CTZ samples were collected, and stained by HE for microscopic observation. Furthermore, their clinical pathological data were carefully reviewed. Results AS a result, the squamous epithelia of all the CTZ samples showed parakeratosis or hyperkeratosis. The zigzag epithelia extended into the stromal layer. Keratinization to different extent even keratin pearl could be found in some parts of epithe- lial feet. The eellular nuelei were large with polymorphism, and most of them were round or oval shaped. The cell nucleoli were prominent, and karyokinesis was rarely seen. Conclusion Since the morphology of CTZ has always been misunderstood as infec- tion warts, sometimes as cervical intraepithelial neoplasia or invasive squamous carcinoma, it ＇ s important to better understand the real clinical pathology of CTZ to avoid misdiagnosis and mistreatment.