摘要
Using the high-resolution Terahertz Time-domain spectroscopy (THz-TDS) and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride (CH), a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77-295 K. Between 0.2 and 3.6 THz (6.6-120.0 cm-1 ), seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.
Using the high-resolution Terahertz Time-domain spectroscopy （THz-TDS） and the standard sample pellet technique, the far-infrared vibrational spectra of clenbuterol hydrochloride （CH）, a 2 -adrenergic agonist for decreasing fat deposition and enhancing protein accretion, were measured in temperature range of 77–295 K. Between 0.2 and 3.6 THz （6.6–120.0 cm–1 ）, seven highly resolved spectral features, strong line-narrowing and a frequency blue-shift were observed with cooling. However, ractopamine hydrochloride, with some structural and pharmacological similarities to clenbuterol hydrochloride, showed no spectral features, indicating high sensitivity and strong specificity of THz-TDS. These results could be used for the rapid and nondestructive CH residual detection in food safety control.
基金
partly supported by the Fundamental Research Funds for the Central Universities
the National Natural Science Foundation of China (Grant Nos. 11104360 and11204191)
Project 985 (Grant no. 98507-010009)
Project 211 of the Ministry of Education of China
the Under graduate Innoviative Test Program funded by Minzu University of China (Grant No. URTP2012-110005)
