氟尿嘧啶经胃左动脉和外周静脉化疗的药代动力学比较

The comparison of 5-FU pharmacokinetics after left gastric artery intraarterial infusion and by peripheral intravenous administration in treatment for gastric carcinoma

目的 探讨胃左动脉区域灌注化疗治疗胃癌的合理性。方法比较氟尿嘧啶（５－ＦＵ）经胃左动脉和外周静脉给药后的药代动力学变化。结果胃左动脉给药组的门静脉血中５－ＦＵ浓度为外周静脉给药组的４～２００倍，而且５－ＦＵ高浓度的维持时间明显延长；癌组织和癌旁淋巴组织中５－ＦＵ水平分别为静脉给药组的１９倍和２３倍。结论胃左动脉区域灌注化疗可明显增加癌肿局部的化疗药物浓度，提高化疗疗效。

Objective To evaluate the legitimation of left gastric regional arterial infusion chemotherapy in the treatment of gastric carcinoma.Methods The pharmacokinetics of 5-FU after different administration routes was studied. Results High concentration of 5-FU was found in blood samples from portal vein by left gastric intraarterial administration,which was 4 - 200 folds of the group by peripheral intravenous administration. The maintainable time of high concentrations of 5-FU by left gastric intraarterial administration was significantly longer than that by peripheral intravenous administration. The concentration of 5-FU in tumor tissues and paratumorous lymphaden by intraarterial administration was 19 times and 23 times of the group by intravenous administration. Conclusion Regional arterial infusion chemotheray can significantly increase the concentration of chemotherapeutic drugs in the tumorous region and improve the chemotherapeutic efficiency.