生长激素受体基因的研究进展

Research Progress in GHR Gene

生长激素受体(GHR)是调控动物生长发育的关键基因之一。近年来,将GHR基因作为家畜生产力的候选基因来探讨提高动物奶肉产量等方面的报道不断增加,已逐渐成为研究热点。该领域的深入探讨可能产生家畜育种和生产中候选基因研究的突破性进展,而且有助于标记辅助选择的实施。文章主要从GHR基因的结构、信号传导途径、GHR表达的组织特异性、GHR多态性与生产性能的关系以及GHR表达的发育性变化等方面进行了综述。

Growth hormone receptor（GHR） is one of the key genes modulating growth and development in animal. As an impor- tant candidate gene of livestock productivity, it becomes gradually research focus for improving meat and milk production in re- cent years. These further researches could lead to breakthrough of candidate gene studies in livestock breeding and production, but also contribute to application of marker assisted selection in practice. This paper reviewed mainly the GHR structure, signal transduction pathway, specificity expression of GHR in tissue, the relationship between GHR polymorphism and production performance, and development change of GHR mRNA expression in animal.