染色体多态性对供精人工授精治疗结局的影响

Influence of chromosomal polymorphism on treatment outcome of artificial insemination by donors.

目的探讨女性染色体多态性与供精人工授精妊娠结局的关系。方法对接受供精人工授精患者常规抽血行染色体检查,将发现有染色体多态的患者作为研究对象,与染色体正常群体对照,观察临床妊娠率、累积妊娠率和早期流产率。结果染色体多态性组与正常组比较,临床周期妊娠率(19.80%vs 19.66%),累积妊娠率(44.82%vs 41.77%),早期流产率(14.58%vs12.07%),均无统计学差异(P>0.05)。结论染色体多态性携带状态不影响供精人工授精患者的治疗结局。

Objective： To investigate the relationship between the female chromosome polymorphism and the pregnancy outcome of artificial insemination by donors.Methods： The peripheral blood of patients was cultured rountinely for karotype analysis.Clinical pregnancy rate,cumulative pregnancy rate and early obortion rate were observed by treated patients with chromosomal polymorphism as the research group,and patients with normal chromosome as control group.Results： There was no significant difference in the clinical cycle pregnancy rate（19.80% vs 19.66%）,cumulative pregnancy rate（44.82% vs 41.77%）,early abortion rate（14.58% vs12.07%） between the two groups（P0.05）.Conclusion： Chromosomal polymorphism carrier status has no impact on treatment outcome of the patients receiving artificial insemination by donors.