妊娠期高血压疾病肾损伤与妊娠结局的相关性研究

The study about the relationship between the kidney injury in gestational hypertension and the pregnancy outcomes.

目的探讨妊娠期高血压疾病肾脏损伤的严重程度与患者病情及妊娠结局的关系。方法将妊娠期高血压疾病患者按尿蛋白(-)、(+)、(2+)、(3+)分为A、B、C、D 4组,每组分别为68、57、35及61例。对4组患者的血压值、血浆白蛋白、肾功能及与围产儿结局相关的各项指标进行统计分析。结果 D组血清尿素、肌酐及尿酸含量、血压值、超声S/D值较其他3组明显升高,且尿蛋白含量越多,尿素、肌酐及尿酸含量越高;D组血浆白蛋白含量、分娩孕周、胎盘重量及新生儿体重明显低于其他3组(P<0.05)。结论妊娠期高血压疾病患者尿蛋白的多少与肾功能的损伤程度、患者病情及围产儿结局相关。

Aim： To explore the relationship between the severity of kidney injury in gestational hypertension and the pregnancy outcomes.Methods： Divided the patients with gestational hypertension into four groups according to the severity of proteinuria.There are 68,57,35 and 61 patients in A,B,C and D group respectively according to the content of proteinuria as（-）,（＋）,（2＋） and（3＋）.To analyze the blood pressure,plasma albumin,renal function and some index implying the outcomes of neonates.Results： The urea,creatinine and uric acid value,blood pressure,S/D value of fetal ultrasound of group D were significantly increased compared with other three groups.The value of urea,creatinine and uric acid is related with the content of proteinuria.The content of plasma albumin was lower,the termination of pregnancy was significantly earlier,and the placental and neonatal weight was lighter in group D than in other three groups（P0.05）.Conclusion： The severity of proteinuria is related to the kidney injury,patients＇ condition and fetal outcome of gestational hypertension.