胎儿生长受限与母血中甲状腺素关系的研究

Study on the relationship between fetal growth restriction(fgr) and maternal serum thyroid hormone.

目的探讨FGR与孕妇血清中甲状腺素的关系。方法采用放射免疫分析法,测定正常足月妊娠38例(正常组)和足月妊娠FGR 22例(FGR组)孕妇血清中甲状腺素(T4)、三碘甲状腺原氨酸(T3)、游离T4(FT4)、游离T3(FT3)、促甲状腺素(TSH)水平,比较两组甲状腺素水平。结果 FGR组孕妇血清TSH高于对照组(P<0.01),T4、T3、FT4、FT3均低于对照组,其中T4、FT4差异有显著性意义(P<0.05)。结论 FGR的发病可能与甲状腺功能低下有关。

Objective： To investigate the relationship between fetal growth restriction（FGR） and thyroid hormone in maternal blood.Methods：22 termed pregnancies with FGR（FGR group） and 38 normal termed pregnancies（normal group） were studied.Maternal blood were collected from all the cases.The levels o f thyroxin（T4）,triiodothyronine（T 3）,free T4（FT4）,free T3（FT3） and thyroid-stimulating hormone（TSH） were measured by immunoradiometric assay（IRMA）technique,and were compared between each group.Results：The TSH was higher in FGR group than that in the normal group（P0.01）.The T4,FT4 was lower in FGRs group than that in the normal group（P0.05）.Conclusions： This study confirmed the pathogenesis of FGR may be connected with the functional decay of thyroid.