L-苯丙氨酸与β,γ-不饱和酮酸酯的[3+2]环加成反应

L-phenylalanine and β,γ-Unsaturated Keto Esters of [3+2] Cycloaddition

运用简单的L-苯丙氨酸与β,γ-不饱和酮酸酯的[3+2]环加成反应合成吡咯衍生物,在80℃条件下能取得最好68%的产率,达到2∶1的区域选择性,合成了8个未见文献报道的取代的吡咯衍生物,其结构得到1H NMR,HRMS确证.

The L-phenylalanine and fl, T-unsaturated ketone acid ester of [ 3 ＋ 2 ] cycloaddition reaction , at 80℃ can get 68% yield and 2：1 regioselectivity. In this paper , we have synthesized 8 derivatives of tile piperidines,and its structures were confirmated by 1H NMR , HRMS.