血管介入诊疗引发造影剂肾病的研究进展

Research progress in contrast-induced nephropathy in vascular interventional therapy

随着现代诊治技术的发展,血管造影技术的应用日益广泛,经常需要使用大剂量含碘造影剂,因此,造影剂肾病(CIN)的发生率亦随之增加,目前CIN已成为医院获得性肾功能不全的第三位原因,在药物损害所致的肾衰竭中位居第二位。如何防治介入检查和治疗过程中引发的肾脏损害日益受到医学界的关注。该文就CIN的发病机制、危险因素、早期肾损害的标志物及其防治等方面的研究进展进行综述。

With the development of modern diagnosis and treatment techniques,the use of vascular interventional therapy becomes widespread.Large doses of iodinated water soluble contrast media（CM） are often administered during neural interventional procedures.Then the incidence of contrast-induced nephropathy（CIN） is increasing now.CIN has become the third cause of hospital acquired renal failure and the second most important reason of drug-induced renal failure.How to preventing CIN effectively during interventional procedures is increasingly subject to the attention of the medical profession.This paper reviewed the risk factors and pathogenesis,as well as the early renal damage markers,prevention and cure of CIN.