己糖激酶Ⅱ与肿瘤研究进展

Hexokinase-Ⅱ and tumor

肿瘤最显著的代谢特征是高效糖酵解,即Warburg效应。肿瘤糖酵解活跃程度与肿瘤生长速度和侵袭性密切相关。尽管肿瘤高效糖酵解机制涉及癌基因事件,但糖酵解关键酶异常在肿瘤Warburg效应中起主要作用,其中己糖激酶Ⅱ(HK-Ⅱ)在恶性肿瘤中表达、亚细胞分布和酶动力学改变更显著,并且与肿瘤特征性代谢表型、细胞增殖和凋亡调节密切相关。HK-Ⅱ可能是探索肿瘤诊断和治疗的潜在靶点。

The most significant metabolic features of malignant tumors is their highly effective glycolysis, i.e., the ＂Warburg effect＂ . The active degree in tumor glycolysis is closely related to cancer growth and aggressive. Although the mechanism of efficient glycolysis in tumor are involved in oncogene events, the abnormalities of key enzymes in glycolysis, play a pivotal role in tumor Warburg effect. Among others, there is more significant aherations of hexokinase-Ⅱ （ HK-Ⅱ） in the expression, subcellular distribution and kinetics, and which is is bound up with the prominent metabolic phenotype, proliferation and apoptosis of malignant cell. HK-Ⅱ may be a potential target for exploring the diagnosis and therapy of tumor.