期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA突变和miRNAs失调在结肠癌早期诊断中的研究进展 被引量：5

下载PDF
导出
摘要 结直肠癌（Colorectal Cancer,CRC）是人类最常见的消化系统恶性肿瘤之一。放眼世界,CRC在上皮细胞恶性肿瘤中位列第三位,所有的癌症死亡中,由它引起的超过了10%[1]。2012年6月举行的第八届上海国际CRC高峰论坛公布的权威数据显示：CRC的发病率在我国呈现逐年上升趋势,发病率已由20世纪70年代初的12/（10万）增长到目前的56/（10万）,升速约为每年4.2%,远高于2%的国际水平。目前,我国CRC的发病数已超过美国,发病率在所有肿瘤发病率中排名第5位。现阶段CRC的早期诊断状况不尽如人意,
作者 臧健 俞林
机构地区 广西医科大学第一附属医院结直肠肛门外科
出处 《结直肠肛门外科》 2012年第6期399-404,共6页 Journal of Colorectal & Anal Surgery
关键词 早期诊断 MIRNAS DNA突变 消化系统恶性肿瘤 结肠癌 失调 CRC 发病率
分类号 R735.35 [医药卫生—肿瘤]
  • 相关文献

参考文献55

  • 1Jemal A, Siegel R,Xu J, et al. Cancer statistics [J]. CA:A Cancer Journal for Clinicians , 2010, 60 (5): 277-300.
  • 2De Mattos-Arruda L,Dienstmann R, Tabernero J. De- velopment of molecular biomarkers in individualized treatment of colorectal cancer[J]. Clinical Colorectal Cancer ,2011,10(4) :279-289.
  • 3Shin H, Markey MK. A machine learning perspective on the development of clinical decision support sys- tems utilizing mass spectra of blood samples[J]. J Bi- omed Inform,2006,39(2) ..227-248.
  • 4Fearon ER,Vogelstein B. A genetic model for colorec- tal tumorigenesis[J]. Cell, 1 990,61 .. 759-767.
  • 5Loganayagam A. Faecal screening of colorectal cancer [J]. International Journal of Clinical Practice, 2008, 62..454-459.
  • 6Zhang W, Bauer M,Croner RS, et al. DNA stool test for colorectal cancer: hypermethylation of the secrete frizzled-related protein-1 gene[J]. Diseases of the Co- lon : Rectum, 2007,50 : 1618-1626.
  • 7Walsh JME, Terdiman JP. Colorectal cancer screening scientific review[J] JAMA, 2003,289 : 1288-1296.
  • 8Sidransky D, Tokino T, Hamilton SR, et al. Identifica- tion of ras oncogene mutations in the stool of patientswith curable eolorectal tumors[J]. Science, 1992,256 (5053) : 102-105.
  • 9Dong SM, Traverso G, Johnson C, et al. Detecting colorectal cancer in stool with the use of multiple ge- netic targets[J]. J Natl Cancer Inst , 2001,93: 858- 865.
  • 10Ahlquist DA. Stool-based DNA tests for colorectal cancer:clinical potential and early results. Rev Gas- troenterol Disord, 2002,2 (1) : 20-26.

二级参考文献13

  • 1Gryfe R, Swallow C, Bapat B, et al. Molecular biology of colorectal cancer.Curr Probl Cancer,1997,21:233-300.
  • 2Petersen GM,Brensinger JD,Johnson KA,et at.Genetic testing and counseling for hereditary forms of colorectal cancer.Cancer,1999,86:2540-2550.
  • 3Forrester K,Almoguera C,Han K,et at. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.Nature,1987,327:298-303.
  • 4Whitlock EP,Lin JS,Liles E,et at.Screening for colorectal cancer:a targeted, updated systematic review for the U.S.Preventive Services Task Force. Ann Intern Med,2008,149:638-658.
  • 5Levin B,Brooks D,Smith RA,et al.Emerging technologies in screening for colorectal cancer:CT colonography,immunochemical fecal occult blood tests, and stool screening using molecular markers.CA Cancer J Clin,2003,53:44-55.
  • 6Pogribny I,raiche J,Slovack M,et al.Dose dependence,sex and tissue specificity,and persistence of radiation induced genomic DNA methylation changes.Biochem Biophys Res Commun,2004,320:1253-1261.
  • 7Chan AO,Rashid A. CpG island methylation in precursors of gastrointestinal malignancies.Curr Mol Med,2006,6:401-408.
  • 8Izmailova ES,Wieczorek E,Perkins EB,et al. A GC-box is required for expression of the human vimentin gene.Gene,1999,235:69-75.
  • 9Zou H,Harrington JJ,Shire AM,et at.Highly methylated genes in colorectal neoplasia: implications for screening. Cancer Epidemiol Biomarkers Prev,2007,16:2685-2696.
  • 10Chipoy C, Brounais B, Trichet V, et al. Sensitization of osteosarcoma cells to apoptosis by oncostatin M depends on STAT5 and p53.Oncogene,2007,26:6653-6664.

共引文献7

同被引文献56

  • 1鲁瑶,潘瑞芹,原田英也,上妻喜腾,高岛茂树,贾振庚.VEGF、MVD和CEA与大肠癌病理学特征及预后相关性的临床研究[J].中国实用外科杂志,2005,25(6):362-364. 被引量：12
  • 2顾国利,任力,黄蓉蓉,魏学明,李德昌,戴大江,王石林.大肠癌免疫组化表达与临床病理的关系[J].世界华人消化杂志,2006,14(28):2765-2770. 被引量：7
  • 3Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010[J]. CA Cancer J Clin, 2010, 60(5): 277-300.
  • 4Chen CC, Yang SH, Lin JK, et al. Is it reasonable to add preopera- tive serum level of CEA and CAl9-9 to staging for colorectal Cancer [Jj. J Surg Res,2005,124(2) :169-174.
  • 5De Mattos-Arruda L, Dienstmann R, Tabernero J. Development of molecular biomarkers in individualized treatment of colorectal canc- er[ J ]. Clin Colorectal Cancer,2011,10 (4) :279-289.
  • 6Kimura K, Nagasaka T,Hoshizima N. No duplicate KRAS mutation is identified on thesame allele in gastric or colorectal cancer cells with multiple KRAS mutations[J]. J Int Med Res,2007,35(4):450-457.
  • 7Lenhard K, Bommer GT, Asutay S, et al. Analysis of promoter meth- ylation in stool: a novel method for the detection of colorectal cancer [ J ]. Clin Gastroenterol Hepatol,2005,3 (2) : 142-149.
  • 8Manikandan J, Aarthi J J, Kumar SD, et al. Oncomirs : the potential role of non-codingmicroRNAs in understanding cancer [ J ]. Bioin- formation ,2008,2 ( 8 ) :330-334.
  • 9Mourtzikou A, Stamouli M, Kroupis C, et al, Evaluation of carci- noembryonic antigen (CEA), epidermal growth factor receptor (EGFR) , epithelial cell adhesion molecule EpCAM (GA733-2), and carbohydrate antigen 19-9 (CA 19-9 ) levels in colorectal cancer patients and correlation with clinicopathological characteris- tics[J]. Clin Lab ,2012,58(5-6) : 441-448.
  • 10X Zhang,J Wang,W Qian,et al.Dexmedetomidine Inhibits Tumor Necrosis Factor-Alpha and Interleukin 6 in Lipopolysaccharide-Stimulated Astrocytes by Suppression of c-Jun N-Terminal Kinases [J].Inflammatio-n,2014,37 (3) :942-949.

引证文献5

二级引证文献11

结直肠肛门外科
2012年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部