转化生长因子β_1表达与非小细胞肺癌淋巴结转移及预后的关系

THE RELATIONSHIP BETWEEN EXPRESSION OF TRANSFORMING GROWTH FACTOR β_1 AND LYMPH NODE METASTASIS,PROGNOSIS OF NON-SMALL CELL LUNG CARCINOMA

1目的 探讨转化生长因子 β1 (TGFβ1 )在非小细胞肺癌中表达的意义。 2方法 应用免疫组化法检测了 12 1例非小细胞肺癌标本中 TGFβ1 的表达。 3结果 TGFβ1 在肺癌中的阳性表达率为 77.7% ,其阳性表达分为间质型和胞浆型 ,表达类型与肺癌淋巴结转移及预后有关。淋巴结转移阳性组中 TGFβ1 的间质阳性表达率显著低于阴性组 ,而其胞浆阳性表达率显著高于阴性组 (χ2 =10 .0 1,2 1.98,P<0 .0 1) ;0 .5年内死亡组的 TGFβ1 间质阳性表达率显著低于生存 >5 .0年组 ,而间质胞浆均阳性及胞浆阳性表达率则显著高于生存 >5 .0年组 (χ2 =8.2 1,7.6 3,P<0 .0 5 )。 4结论 TGFβ1 表达与肺癌恶性生物学行为关系明显 ,是估测病人预后的有效参数之一。

Objective To study the significence of transforming growth factor β 1(TGF β 1) in non small cell lung carcinoma(NSCLC).\ Methods\ The expression of TGF β 1 was detected in 121 cases of NSCLC with immunohistochemistry.\ Results TGF β 1 had two types of expression: mesenchymal type and cytoplasma type; the total positive rate was 77.7%. The type of TGF β 1 expression was related with lymph node metastasis and prognosis of patients; the positive rate of TGF β 1 expression only in mesenchyma in the group of lymph node metastasis patients was significently lower than that in no lymph node metastasis patients, but the positive rate of TGF β 1 expression only in cytoplasma was higher. The expression of TGF β 1 only in mesenchyma in the group died within 0.5 year was lower than the group patients lived more than 5.0 years.\ Conclusion\ The expression of TGF β 1 protein is correlated with malignant biological behavior of NSCLC, and has important value on predicting the prognosis of patient with NSCLC. [