摘要
1目的 探讨载脂蛋白 E(Apo E)基因多态性与脑梗死的关系。 2方法 采用 PCR- RFL P技术检测了 37例动脉粥样硬化性血栓性脑梗死病人及 2 6例腔隙性脑梗死病人的 Apo E基因型 ,并与 30例健康人进行了比较 ,同时检测了血脂及载脂蛋白 A和 B.3结果 动脉粥样硬化性血栓性脑梗死组 E4等位基因频率较对照组显著增高 (χ2 =8.40 ,P<0 .0 1) ,而 E3基因频率较对照组降低 (χ2 =6 .37,P<0 .0 5 )。 4结论 Apo E基因多态性与动脉粥样硬化性血栓性脑梗死的发病有关 ,E4基因可能为该病的危险因子。
Objective To explore the relationship between apolipoprotein E polymorphism and cerebral infarction. Methods\ The genotype was studied by PCR RFLP in 63 patients with cerebral infarction(37 atherothrombotic and 26 lucunar type) and in 30 healthy age matched subjects.\ Results\ Patients with atherothrombotic cerebral infarction(ACI) had a higher E4 allele frequency than the control group( χ 2=8.40,P <0.01), and a lower E3 frequency( χ 2=6.37,P <0.05).\ Conclusion\ ApoE polymophysims may be associated with ACI and E4 allele could probably be a predisposing risk marker for the disease. [
出处
《青岛大学医学院学报》
CAS
2000年第4期265-267,共3页
Acta Academiae Medicinae Qingdao Universitatis
