P53蛋白在皮肤基底细胞癌中的表达

EXPRESSION OF P53 PROTEIN IN BASAL CELL CARCINOMA OF HUMAN SKIN

1目的 探讨 P5 3蛋白表达与皮肤基底细胞癌的临床及组织学特征之间的关系 ,以期阐明皮肤基底细胞癌的发病机制 ,为临床诊疗提供理论依据。2方法 42例经常规石蜡包埋皮肤基底细胞癌标本 ,镜检确定组织学类型 ,应用免疫组织化学 S- P法检测 P5 3蛋白表达。 3结果 42例皮肤基底细胞癌中 ,18例 P5 3蛋白表达阳性 ,阳性表达率为 42 .85 % ;9例强阳性 ,强阳性表达率为 2 1.40 % .P5 3蛋白表达与皮肤基底细胞癌的组织学类型无关(χ2 =1.38,P>0 .0 5 )。 4结论 P5 3蛋白表达与皮肤基底细胞癌有着密切关系 ,在其发病中起着重要作用。

Objective\ To study the relationship between P53 protein expression and histologic character of basal cell carcinoma(BCC). To clarify the mechanism of BCC and provide theoretical basis for clinical therapy and diagnosis.\ Methods 42 paraffin embedded specimens of BCC were identified under light microscopy. P53 protein expression was observed using S P immunohistochemistry.\ Results\ The positive expression of P53 protein was found in 18 of 42 specimens of BCC(42.85%). P53 protein strong positive expression rate was 21.40%. The expression of P53 protein was not related to its histological types ( χ 2= 1.38 ,P >0.05).\ Conclusion\ The P53 protein expression has close relation to BCC, which may play an important role in the pathogenesis of BCC. [