原癌蛋白C-erbB-2和PCNA在乳腺病变中表达及意义

Expression of oncoprotein CerbB-2 and PCNA in malignant and benign breast diseases and its clinical significance

目的 :检测原癌基因蛋白 C- erb B- 2和增殖细胞核抗原 (PCNA)在乳腺良恶性病变中的表达及意义。方法 :采用免疫组化法。结果 :C- erb B- 2和 PCNA在乳腺良恶性病变中表达差异显著(P<0 .0 1 )。其中导管内乳头状瘤病中二者表达高于其它良性病变而低于乳腺癌 (P<0 .0 1 )。乳腺癌中 C- erb B- 2和 PCNA表达与肿物大小和组织学分级呈正比 (P<0 .0 5)与 ER水平和 5年生存期呈反比 (P<0 .0 1 )。结论 :C- erb B- 2和 PCNA高表达者组织分化差 ,预后不良。C- erb B- 2和PCNA可作为判定潜在恶性程度的乳腺良性病变及乳腺癌预后的指标。

? Objective:To examine the expression of CerbB-2 and PCNA in malignant and benign breast diseases and its clinical significance.Methods:Immunohistochemical study was used.Results:The expression of CerbB-2 and PCNA in malignant and benign breast diseases were statistically significant ( P <0 01 ).The expression of CerbB-2 and PCNA in breast intraductal papillomatosis was higher than that in other benign diseases and lower than that in breast cancer ( P <0 05).The positive rates of CerbB-2 and PCNA in breast cancer were closely correlated with tumor size and histological grading ( P <0 05) .And they were negatively correlated with the level of estrogen receptor and the survival duration ( P <0 01).Conclusion:The results suggest that the over-expression shows a poor prognosis and short survival duration.CerbB-2 and PCNA might help in distingushing malignant and benign breast diseases. 〔