阿托伐他汀对老年血脂正常冠心病患者治疗疗效及预后影响

Effect of Atorvastatin in Elderly Coronary Artery Disease Patients with Normal Lipid and Its Influence for Prognosis

目的探讨阿托伐他汀治疗老年血脂正常冠心病患者的临床疗效及预后。方法将108例老年血脂正常的冠心病患者随机分为两组,52例对照组患者给予常规治疗,56例观察组患者在常规治疗基础上口服阿托伐他汀,比较两组治疗前后的血脂、颈动脉内膜-中层厚度(IMT)及左室射血分数(LVEF)。结果治疗后观察组血清甘油三脂(TG)、胆固醇(TC)及低密度脂蛋白(LDL)均显著优于对照组(P<0.05);随访6月内,观察组心绞痛、急性心肌梗死、严重心律失常发生率均显著低于对照组(P<0.05);治疗后观察组IMT值显著低于对照组,而LVEF显著高于对照组(P<0.05)。结论阿托伐他汀治疗老年血脂正常冠心病患者,控制血脂效果更为理想,可延缓动脉粥样硬化的进展,显著降低心血管事件发生率,改善患者心功能和预后。

Objective To explore the effect of atorvastatin in elderly coronary artery disease patients with normal lipid and its influence for prognosis. Methods 108 elderly coronary artery disease patients with normal lipid were randomized into two groups. 52 cases of control group were given routine treatment and 56 cases of experiment group were orally taken atorvastatin based on routine treatment. Lipid, IMT and LVEF before and after treatment were compared. Results TG, TC and LDL after treatment in experiment group were superior to control group （P〈0.05）; The experiment group had lower occurrence of angina pectoris, acute myocardial infarction and severe arrhythmia during follow up period than the control group （P 〈0.05）; Compared with control group, IMT greatly decreased and LVEF increased after treatment in experiment group （P 〈0.05）. Conclusions Atorvastatin in elderly coronary artery disease patients with normal lipid has ideal effect, which can delay progress of atherosclerosis, decrease major cardiovascular events, improve heart function and prognosis.