肾气丸对原发肾病综合征患者外周血糖皮质激素受体水平的影响

Effect of Shenqi Pills on Glucocorticoid Hormone Receptor Level of Peripheral Blood of Patients with Nephrotic SYndrome

目的 :旨在通过观察肾气丸对原发肾病综合征患者外周血糖皮质激素受体 (GCR)水平的影响 ,分析其药理机制。方法 :选原发性肾病综合征患者 6 3例 ,分中西结合组和西药对照组临床治疗。结果 :肾气丸合用糖皮质激素 (GC)治疗肾病综合征与单纯用GC治疗相比 ,前者用药 2 4h后GCR水平明显高于后者 ,这与提高GC对肾病综合征疗效的机理有关。结论

Objective:To analyze the pharmacological mechanism of Shenqi Pills through the investigation on its effect on glucocorticoial hormone receptor(GCR) level of peripheral blood of patients with nephrotic syndrome.Methods:63 patients with primary nephrotic syndrome were selected and divided into the intergrated traditional Chinese medicine and western medicine group and western medicine control group. Patients were treated with Shenqi Pills plus glucocorticoid hormone(GC) and single GC, respectively.Results:GCR level of the former in 24 hours after they took medicine was greatly higher than the later. It was relevant to the mechanism of raising the curative effect of GC on nephrotic syndrome.Conclusion:Shenqi Pills with GC combinnation use is effective for nephrotic syndrome.