不同剂型去甲斑蝥素肝脏注射急性毒性比较

Comparison of Acute Toxicities of Liver Injection of different Dosage Forms of Nor cantharidin

目的 :比较去甲斑蝥素缓释注射剂型与普通注射液肝脏注射的急性毒性 ,为缓释剂型的临床肝脏注射应用提供实验依据。方法 :6 0只小鼠及 18只大鼠各随机分为 3组 ,分别肝脏注射等量去甲斑蝥素缓释溶液、普通水剂及药物缓释辅料泊洛沙姆 40 7溶液 ,观察小鼠行为状态、生存情况及大鼠肝脏病理形态学变化。结果 :注射去甲斑蝥素缓释溶液组小鼠死亡率低于普通水溶液组 ;泊洛沙姆 40 7小鼠肝脏注射的LD50 >6 2 5mg/kg ;缓释制剂对注射部位肝脏的刺激毒性较普通制剂大 ,坏死范围广。结论 :去甲斑蝥素缓释制剂肝脏注射毒性低于普通制剂 ,缓释制剂肝肿瘤内注射安全。

Objective:To compare the acute toxicities of liver injection of repository injection and ordinary injection of nor cantharidin to provide an experimental basis for the clinical application of liver injection of repository preparation.Methods:60 mice and 18 rats were divided into 3 groups at random and given repository solution, ordinary water injection and drug repository assistant:P407 solution, respectively in liver injection. The behavior states, survival conditions of mice and liver pathomorphology changes of rats were Observed.Results:The death rate of mice in the repository solution group was lower than that in the ordinary water injection group. LD 50 of P407 solution (liver injection) was larger than 625mg/kg. The irritation toxicity of repository preparation in the injection part of liver was larger than that in the ordinary preparation. The necrosis range was also wide.Conclusion:The liver injection toxicity of Nor cantharidin Repository preparation is lower than that of the ordinary preparation. The liver tumor injection of repository preparation is safe and feasible.