透明质酸对人工关节材料的润滑作用

Lubricating Behaviour of Hyaluronic Acid in Artificial Articular Materials

配合人工软骨材料的研究，探讨透明质酸（HA）作为摩擦副的人工滑液时的润滑性能．在PVA-H／316L，PVA-H／PVA-H两类摩擦副上，利用锥板式粘度计、改进后的振子式摩擦仪和M2000型磨损试验机，测定了不同质量分数的HA溶液的流变性质、摩擦性能和磨损性能．结果表明，HA溶液一定程度上具有天然滑液的流变性质，并有效地降低了摩擦副的摩擦磨损，其对PVA-H／PVA-H摩擦副润滑作用更佳，且0．75％（质量分数）的HA溶液表现出优于体积分数为30％小牛血清的润滑性能，可认为HA是很有前途的人工滑液．

Supporting the study of artificial articuar cartilage materials, the research and development of an artificial synovial fluid of Hyaluronic acid (HA) was carried out. With two lubricated sliding pairs, PVAH/316L and PVA-H/PVA-H, an modified oscillator-type tri-biometer and M-2000 wear test machine were used to detemine the rehological properties and lubricating behaviour of a series of HA solution.The experimental results showed that the solution of HA had the rehological properties similaring to the natural synovial fluid to a cehain eXtellt, and decreased the ffiction and wear of tWo kinds of lubricatCd sliding pairs, also it rendered abetter 1ubricating effection on PVA-unVA-H than on PVA-H/3 l6L. The sofution of HA with O.75% (massfraction) showed a better lubricating behaviour than 30% (volumic fraction) Bovine Serum. So HA solutionwould be a promising Anficial synovial fluid.