妊娠期糖尿病患者血清白介素-6,肿瘤坏死因子-α和高敏-C反应蛋白的意义

Significance of serum interleukin-6,tumor necrosis factor-α and high sensitivity-C reactive protein in patients with gestational diabetes

目的观察妊娠期糖尿病（GDM）患者血清白介素-6（IL-6）、肿瘤坏死因子-a（TNF-Ot）和高敏一C反应蛋白（hs-CRP）的意义。方法选择2010年1月～2012年6月在上海市奉贤区中心医院妇产科产检的单胎孕妇436例，根据葡萄糖筛选试验和葡萄糖耐量试验，分为GDM组，糖耐量受损（IGT）组和正常对照组（NGT组），并观察IL-6、TNF-d、hs-CRP和糖化血红蛋白（HbAlc）的变化。结果与IGM组和NGT组比较，GDM组的IL-6、TNF-a、hs-CRP和HbA。水平出现明显升高，差异有高度统计学意义（P〈0．01）。根据患者HbA。的水平，分为〈6．5％组为33例，6．5％～8．5％组为41例和〉8．5％组为81例。孕妇血清IL-6、TNF-a和hs-CRP水平随着HbA。的升高，而逐渐升高．差异有高度统计学意义（P〈0．01）。结论GDM孕妇的血清IL-6、TNF-a和hs-CRP水平出现明显升高，IL-6、TNF-a和hs-CRP可能参与了GDM的发病过程。

Objective To observe the significance of serum interleukin-6, tumor necrosis factor-a, and high sensitivity-C reactive protein in patients with gestational diabetes （GDM）. Methods 436 patients with singleton pregnancy in department of gynaecology and obstetrics, the central hospital of Fengxian District in Shanghai City from January 2010 to June 2012, according to the glucose screening test and the oral glucose tolerance test, were divided into GDM group, impaired glucose tolerance （IGT） group and normal control group （NGT group）, and the changes of IL-6, TNF- CL, hs-CRP and glycosylated hemoglobin （HbAlc） were observed in each group. Results Compared with the IGM group and the NGT group, the levels of IL-6, TNF-a, hs-CRP and HbA,, significafitly increased in GDM, the difference was statistically significant （P 〈 0.01）. According to HbAlc, levels, the patients with GDM were divided into 〈6.5% group （33 cases）, 6.5%-8.5% group （41 cases） and 〉 8.5% group （81 cases）. The levels of IL-6, TNF-a and hs-CRP increased, as the levels of HbA,, increased gradually, and the difference was statistically significant （P 〈 0.01）. Conclusion The levels of IL-6, TNF-a and hs-CRP significantly increase in pregnant women with GDM, IL-6, TNF-a and hs-CRP may be involved in the pathogenesis of GDM.