干扰素阻断乙型肝炎病毒父婴传播临床研究

Clinical research for interferon bocks the parent infant transmission of hepatitis B virus

目的研究干扰素阻断父婴传播乙型肝炎病毒（HBV）的效果。方法选择2005年2月～2012年3月在惠州市第一人民医院及惠州市中心人民医院就诊的460例男性慢性HBV感染者及所生新生儿进行研究。研究组为230例接受干扰素治疗并停药的患者及半年后其与配偶自然受孕所生新生儿：对照组为230例不愿接受抗病毒治疗的患者与其配偶自然受孕所生新生儿。观察两组患者生育前HBV定量水平及两组所生新生儿HBV感染情况。结果HBV父婴传播高风险阈值为≥1．O×10^6 copies／mL。干扰素治疗后，父婴传播风险下降31．87％，而对于高病毒载量患者，父婴传播率无明显改变。结论HBV水平高者，其子代感染HBV可能性大；干扰素治疗后HBV垂直传播的风险明显下降。但对于过高病毒载量患者，干扰素疗效欠佳。

Objective To study the blcoking effect of interferon on the paternal-fetal transmission of hepatitis B virus. Methods All of 460 male patients with chmnic hepatitis B virus infection and their neonates in Huizhou hospital from February 2005 to March 2012 were recrutied for research. The study group contains 230 cases, whose fathers were treated with recombinant human interferon crib, and withdrawal six months before the infants born to naturally. The control group were 230 neonates, whose fathers refused to accept the anti-viral therapy. The HBV DNA levels of fathers were detected before breeding and the hepatitis B virus infection circumstances of all infants were observed. Results The high-risk threshold of parent infant transmission of HBV ≥1.O×10^6 copies/mL. After the treatment of interferon, the risk of parent infant transmission were reduced by 31.87%, while for the patients with high viral load, the rate of pater- nal-infant vertical transmission was not changed. Conclusion The possibility of offspring infected with hepatitis B virus were associated with the levels of HBV viral load. After the treatment of interferon, the risk of vertical transmission of HBV decreased significantly. It＇s poor response to the interferon therapy which the patients with high viral load.