联合用药治疗重度子痫前期的效果观察

Observation on effect of combining drugs to treat severe preeclampsia

目的采取联合用药的方法观察对重度子痫前期的临床效果。方法选择2010年1月～2011年12月在郑州大学第一附属医院住院的重度子痫前期患者72例,将患者分为两组。按常规治疗的37例患者为对照组,另35例为治疗组,在对照组基础上加用低分子肝素、尼莫地平、丹参注射液联合治疗,观察两组患者治疗前后不同时段平均动脉压变化情况、治疗前后24 h尿量及尿蛋白、抽搐次数比率的变化。结果与治疗前比较,两组治疗后12、24 h平均动脉压明显降低,尿量增多及尿蛋白减少,差异有统计学意义(P<0.05)。治疗后,与对照组比较,治疗组平均动脉压明显降低,尿量增多及尿蛋白减少,差异有统计学意义(P<0.05)。与对照组比较,治疗组抽搐次数比率明显减少,差异有统计学意义(P<0.05)。结论联合用药对重度子痫前期治疗效果明显,可以较好地预防和控制预防子痫发作。

Objective To observe the clinical effects of drug combination therapy for severe preeclampsia. Methods 72 patients with severe preeclampsia admitted to the first affiliated hospital of Zhengzhou University from January 2010 to December 2012 were divided into two groups. The control group （37 cases） was treated by conventional methods, while the treatment group （35 cases） was treated by combination of low molecular heparin, Nimodipine and Danshen Injection on the basis of conventional methods. Before and after treatment, the mean arterial pressure changes in different period, urine volume and urine protein in 24 hours, convulsion frequency ratio changes of two groups were observed. Results After treatment for both groups, the mean arterial pressure of 12 and 24 hours had been significantly reduced, urine volume increased and urine protein decreased, with statistically significant differences （P 〈 0.05） compared with those before treatment; in the treatment group, mean arterial, pressure significantly reduced, urine volume increased and urine protein decreased, with statistically significant differences （P 〈 0.05） compared with control group; the convulsion frequency ratio of treatment group in different period had been reduced with statistically significant differences （P 〈 0.05） compared with that of control group. Conclusion Drug combination therapy has marked effect for severe preeclampsia, can better prevent and control the attack of preeclampsia.