肝细胞癌中Survivin、Livin蛋白的表达及其临床意义

The expression and clinical significance of Survivin, Livin in hepatic cell carcinomac

目的探讨原发性肝细胞癌组织中Survivin和Livin蛋白表达情况及其相关性,同时结合临床病理因素进行分析。方法采用免疫组化法检测60例原发性肝细胞癌组织及40例癌旁组织中Survivin、Livin蛋白的表达。结果癌及癌旁组织中Survivin蛋白阳性表达率分别为68.3%、10.0%,Livin蛋白分别为58.3%、5.0%,差异有统计学意义(P<0.01)。癌组织中Survivin和Livin蛋白表达与组织分级、肿瘤转移相关(P<0.05),与患者年龄、性别、肿瘤直径大小、术前甲胎蛋白水平无关(P>0.05)。Survivin与Livin蛋白的表达无相关性(P>0.05)。结论 Survivin及Livin蛋白在原发性肝细胞癌组织中表达均显著上调,并与肝癌生物学行为关系密切。

Objective To investigate the expression of Survivin and Livin as well as their correlation in tissue of HCC. Methods The expression of Survivin and Livin were detected in 60 cases of HCC and 40 eases of adjacent normal tis- sue specimens by immunohistoehemieal method. Results The expression rates of Survivin in carcinoma and adjacent normal tissue specimens were 68.3%, 10.0% respectively, the expression rates of Livin in carcinoma and adjacent nor- mal tissue specimens were 58.3%, 5.0% respeetieely, the difference was statistically significant （P 〈 0.01）. The ex- pression of protein Survivin and Livin was closely correlated with tumor grade, metastasis （P 〈 0.05）, but not correlated with age, sex, the diameter of the tumor and AFP content in HCC （P 〉 0.05）. There was no significant correlation be- tween the expression of Survivin and Livin （P 〉 0.05）. Conclusion The expression of Survivin and Livin in HCC in- crease significantly and have close correlation with biological behavior of HCC.