美托洛尔、地尔硫卓及西地兰治疗快速型房颤的效果对比观察

The compared of the effect of Metoprolol, Diltiazem and Cedilanid for rapid atrial fibrillation

目的比较美托洛尔、地尔硫卓及西地兰治疗快速型房颤的临床效果。方法选择102例快速型房颤患者,随机均分为3组,美托洛尔组使用美托洛尔注射液治疗,地尔硫卓组使用地尔硫卓注射液治疗,西地兰组使用西地兰注射液治疗,比较3种药物治疗后120min内不同时间点患者心室率的变化,并统计治疗前后患者血压变化情况。结果美托洛尔组治疗后5min患者心率即出现显著下降,低于治疗前(P<0.05),且显著低于地尔硫卓组和西地兰组(P<0.05),治疗后120min美托洛尔组收缩压和舒张压均显著高于地尔硫卓组(P<0.05)。结论美托洛尔治疗快速型房颤起效迅速,对患者血压影响小,可以作为快速型房颤治疗的首先药物。

Objective To compare the effect of Metoprolol, Diltiazem and Cedilanid for rapid atrial fibrillation： Meth- ods One hundred and two cases of patients with rapid atrial fibrillation were randomly divided into 3 groups, Metopro- lol group was given Metoprolol injection, Diltiazem group was given Diltiazem injection and Cedilanid group was given cedilanid injection, then the changes in ventrlcular at different time after 120 rain treatment were compared in the three groups and blood pressure changes were statisticed before and after treatment. Results Heart rate after 5 min treatment in Metoprolol group was decreased, it was lower than before（P 〈 0.05 ）, and lower than Dihiazem group and Cedilanid group （P 〈 0.05）, systolic and diastolic blood pressure in 120 rain after treatment in Metoprolol group were higher than Diltiazem group （P 〈 0.05）. Conclusion Metoprolol is the most effective treatment method of rapid atrial fibrillation, it has minimal impact on blood pressure, it can be used as the first drug treatment.