非小细胞肺癌同步化疗和三维适形放疗的临床疗效

Clinical efficacy of concurrent chemotherapy and three-dimensional conformal radiotherapy for non-small cell lung cancer

目的探讨同步化疗和三维适形放疗治疗III期非小细胞肺癌的临床疗效。方法 60例III期非小细胞肺癌患者根据治疗方法的不同分为观察组与对照组各30例,两组均采用同步化疗和放疗,对照组采用传统放疗,观察组采用三维适形放射治疗。结果两组患者全部完成治疗,观察组局部控制率为90.0%,对照组为66.7%,两组差异有统计学意义(P<0.05)。两组患者食管与肺部副反应例数与程度对比差异均无统计学意义(P>0.05)。放射剂量40Gy及放疗结束时,两组患者心肌肌钙蛋白I(cTnI)血清浓度差异有统计学意义(P<0.05)。结论非小细胞肺癌同步化疗和三维适形放疗提高了近期疗效,早期放射性损伤未见加重,有利于心肌保护,临床应用安全有效。

Objective To investigate the clinical efficacy of chemotherapy and three-dimensional conformal radiotherapy for non-small cell lung cancer.Methods 60 cases with III stage non-small cell lung cancer under different treatment were equally divided into observation group and control group,two groups were treated with concurrent chemotherapy and radiotherapy,the control group were given traditional radiation therapy method,the observation group were used three-dimensional conformal radiation therapy method.Results All patients were completed the treatment,the observation group＇s local control rate was 90.0%,while was 66.7% in the control group（P0.05）.The esophageal,pulmonary adverse reaction cases and the degree of two groups had no significant difference（P0.05）.Cardiac troponin I（cTn I） serum concentration of two groups had significant difference in the radiation dose of 40Gy at the end of radiotherapy time（P0.05）.Conclusions Concurrent chemotherapy and three-dimensional conformal radiotherapy for treating non-small cell lung cancer can improve the curative effect,the early radiation injury are not deteriorate,it is in favor of myocardial protection,the clinical application is safe and effective.