新型肿瘤标志物细胞角蛋白19片段2G2诊断肺癌的临床价值

Diagnostic value of a new tumor marker CK19-2G2 for lung cancer

目的探讨新型肿瘤标志物细胞角蛋白19片段2G2（CK19—2G2）血清水平对肺癌的诊断价值。方法采用化学发光法检测并比较了150例肺癌、50例肺炎和150名健康体检者空腹血清中CK19—2G2水平，对比血清CK19—2G2与CYFRA21．1水平对肺癌的诊断效能。结果CK19-2G2诊断肺癌的敏感度和准确度分别为553％（83／150）、80.3％（281／350），而CYFRA21—1诊断肺癌的敏感度和准确度分别为28．0％（42／150）、67．4％（236／350）。CK19—2G2敏感度和准确度高于CYFRA21—1（P〈0．001）。结论新型肿瘤标志物CK19-2G2血清水平能够起到肺癌临床辅助诊断的作用。

Objective To investigate the diagnostic value of a new tumor marker CK19-2G2 for lung cancer. Methods The serum levels of CK19-2G2 in 150 lung cancer patients, 50 pulmonitis patients and 50 healthy controls were detected with chemoluminescence. The diagnostic efficacy between the serum levels of CK19-2G2 and CYFRA21-1 were compared. Results The sensitivity and accuracy of CK19-2G2 were 55.3 % （83/150） and 80.3 % （281/350）, respectively, While the sensitivity and accuracy of CYFRA21-1 were 28.0 % （42/150） and 67,4 % （236/350）, respectively. The differences were significant （P 〈 0.001）, Conclusion The detection of CK19-2G2 may be a new diagnostic tumor marker for lung cancer.