支气管扩张症急性加重期患者的病原学特点

Analysis of the etiologyof the patients with acute exacerbating bronchiectasis

目的分析支气管扩张症急性加重期患者的病原学特点。方法对2009～2012年的64例支气管扩张症急性加重期患者的痰培养进行回顾性分析。结果 64例患者中培养阳性34例,阳性率为53.1%;其中革兰阴性菌32株,革兰阳性菌2株,ESBLs阳性菌3株,前3位是铜绿假单胞菌18株(52.9%)、大肠埃希氏菌4株(11.8%)、肺炎克雷伯杆菌4株(11.8%)。结论支气管扩张症急性加重期患者的病原菌以G-菌特别是铜绿假单胞菌为主,应有针对性地选择对其敏感的抗菌药物,减少耐药菌的产生。

Objective To analyse the bacterial distribution of the patients with acute exacerbations of bronchiectasis. Methods We performed a retrospective investigation, 64 patients with acute exacerbations of bronchiectasis, who were hospitalized in 2009 to 2012 carried on the analysis of sputum bacterial cultivation. Results The sputum bacterial cul- tivation positive 34 cases among the 64 bronchiectasis patients （53.1%）. The 32 strains of Gram-negative bacteria, 2 strains of Gram-positive bacteria, 3 strains of ESBLs positive, the top 3 are： Pseudomonas aeruginosa strain 18 （52.9%）, Escherichia coli （11.8%）, 4 strains of Klebsiella pneumonia in 4 strains （11.8%）. Conclusion The main pathogens of bronehiectasis in patients with acute exacerbation is Gram-negative bacteria, in particular Pseudomonas aeruginosa, It should be targeted to choose their sensitive antibiotics, reduce the emergence ofresistant bacteria.