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DPP-4抑制剂研究进展 被引量：12

Research progress in dipeptidyl peptidase-4 inhibitors
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摘要 DPP-4抑制剂是一类用于治疗2型糖尿病的口服降糖新药,可改善血糖控制,并且不会诱发低血糖和增加体重。与原有药物相比,DPP-4抑制剂在用药安全性方面具有显著的优势。本综述介绍已上市的DPP-4抑制剂及其作用机理和临床研究。 DPP-4 inhibitors are a new class of oral glucose-lowering agents which are used for the treatment of type 2 diabetes mellitus. They can improve glycemic control without inducing hypoglycemia or weight gain. Compared with the original drugs, they have a significant advantage in terms of drug safety. This review introduces the marketed DPP-4 inhibitors, their mechanism of action and clinical trials.
作者 陈卓 张庆文
机构地区 上海医药工业研究院
出处 《上海医药》 CAS 2013年第7期50-54,共5页 Shanghai Medical & Pharmaceutical Journal
关键词 DPP-4抑制剂 2型糖尿病 西格列汀 DPP-4 inhibitors type 2 diabetes mellitus sitagliptin
分类号 R977.15 [医药卫生—药品]
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参考文献22

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共引文献328

同被引文献165

  • 1王全伟,凡文博,王智昊,吴扬.氧化应激与心血管疾病关系的研究进展[J].中国老年学杂志,2014,34(1):270-273. 被引量：61
  • 2刘彦晶.糖尿病并发症发病机制的理论探讨[J].中医药学刊,2004,22(11):2139-2140. 被引量：9
  • 3吕邵华,冯凭.糖尿病并发症的共同机制[J].国际内分泌代谢杂志,2006,26(B04):13-15. 被引量：7
  • 4张石革.双胍类降糖药的作用优势与评价[J].中国医院用药评价与分析,2006,6(5):268-271. 被引量：29
  • 5李洪梅.α-葡萄糖苷酶抑制剂的临床应用[J].中国医刊,2007,42(10):19-21. 被引量：33
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  • 7Lambeir AM, Durinx C, Scharpe S, et al. Dipeptidyl-pepti- dase 1V from bench to bedside: an update on structural prop- erties, functions, and clinical aspects of the enzyme DPPIV [J]. Crit Rev Clin Lab Sci, 2003, 40(3) :209-294.
  • 8Christopherson KW 2nd, Hangoc G, Mantel CR, et al. Mod- ulation of hematopoietic stem cell homing and engraftment by CD26 [Jl. Science, 2004, 305(5686):1000-1003.
  • 9Van der Veken P, Haemers A, Augustyns K. Prolyl peptida- ses related to dipeptidyl peptidase IV : potential of specific in- hibitors in drug discovery [J]. Curr Top Med Chem, 2007, 7(6) :621-635.
  • 10O'Leary H, Ou X, Broxmeyer HE. The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation [ J ]. Curr Opin Hematol, 2013, 20(4) :314-319.

引证文献12

二级引证文献81

上海医药
2013年 第7期

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