疏肝益阳胶囊对动脉性勃起功能障碍大鼠性功能及性腺质量的作用

Effect of Shuganyiyang Capsules on Sexual Function and Sex Gland Weight in Rats with Arteriogenic Erectile Dysfunction

目的观察中药疏肝益阳胶囊对动脉性勃起功能障碍(arteriogenic erectile dysfunction,AED)模型大鼠性功能及睾丸和附属性腺器官质量的改善作用。方法选取3月龄成年雄性SD大鼠50只,采用双侧髂内动脉结扎法复制AED模型。设假手术组、模型组、西地那非组(每日10.5mg/kg)、疏肝益阳胶囊大剂量组(每日1g/kg)、疏肝益阳胶囊小剂量组(每日0.5g/kg),每组10只,灌胃给药,疗程30d。行阿朴吗啡(apomorphine,APO)试验检测性功能,取双侧睾丸及附睾、前列腺、精囊腺、球海绵体肌,称湿质量并计算质量系数。结果 APO试验显示疏肝益阳胶囊大、小剂量可显著增加AED大鼠30min内阴茎勃起次数(P<0.01)。疏肝益阳胶囊大、小剂量可显著增加AED大鼠睾丸、附睾、球海绵体肌质量系数(P<0.05)。结论疏肝益阳胶囊可明显改善AED大鼠的性功能,并可使睾丸及其附属性器官质量系数显著增加。

Objective To observe the effect of Shuganyiyang （SGYY） Capsules （for dispersi liver qi and nourishing yang） cm the svxual function and 1he weights of testes and accessory rats with arteriogenic erectile dysfunction （AED）. Methods Fifty male Sprague-Dawley months were selected in the study. Bilateral internal iliac arteryligation was used to induce a ng stagnat sex glands rats aged rat model ed in AED. The rats were randomly and equally divided into sham operation group, model group, sidenafil （10.5 mg/kg daily） group, high-dose SGYY Capsule （1 g/kg daily） group, and low-dose SGYY Capsule （0.5 g/kg daily） group and received their respective treatments by intragastric administration for 30 d. The sexual function of rats in each group was evaluated by apomorphine （APO） test. The bilateral testes and epididymides, prostate, seminal vesicle, and bulbocavernosus muscle of rats were collected; the wet weight of each organ was measured, and the weight coefficient was calculated. Results The APO test showed that the high-dose and low-dose SGYY Capsule groups had significantly more times of penile erection within 30 min （P〈0.01） and significantly higher weight coefficients of testes, epididymides, and hulbocavernosus muscle （P〈0.05）, as compared with the model group. Conclusion SGYY Capsules can significantly improve the sexual function and weight coefficients of testes and auxiliary sex glands in rats with AED.