摘要
目的探讨坎地沙坦联合卡托普利治疗糖尿病肾病的临床疗效。方法选择糖尿病肾病患者185例随机分为观察组93例、对照组92例,均给予卡托普利治疗,观察组另给予坎地沙坦治疗,对比两组患者收缩压(SBP)、舒张压(DBP)、尿白蛋白排泄率(UAER)、肾小球率过滤(GFR)变化情况,并观察与记录不良反应。结果两组治疗后SBP、DBP均较治疗前显著改善(P<0.05),观察组UAER、GFR方面较治疗前显著改善(P<0.05),对照组UAER、GFR方面与治疗前差异无统计学意义(P>0.05);治疗后观察组在UAER、GFR方面改善显著优于对照组(P<0.05)。结论坎地沙坦联合卡托普利治疗糖尿病肾病疗效显著,可有效降低血压,减少蛋白尿的排泄,改善肾脏的损伤。
Objective To investigate the clinical effect of candesartan combined captopril in diabetic nephropathy. Methods A total of 185 cases patients with diabetic nephropathy were selected and randomzed into observation group （n = 93） and control group （n = 92）,all patients taken treatment with captopril,patients in observation group taken treatment with candesartan in addition,change of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, urinary albumin excretion rate （UAER） and glomerular filtration rate （GFR） were contrasted between observation group and con- trol group,and untoward reaction were observed. Results SBP and DBP was improved after treatment in two group（P 〈 0.05） ,UAER and GFR was improved after treatment in observation group P 〈 0.05）, and was incariant in control group（P 〉 0.05） ,change of UAER and GFR wasprevalent in bservation group to in control group （P 〈 0.05）. Conclu- sion Candesartan combined captopril has notable curative effect in diabetic nephropathy.and can notablely degrade blood pression,decrease excretion of urine protein and improve kidney injury.
出处
《中国现代医生》
2013年第6期42-43,共2页
China Modern Doctor
