口服氨甲环酸片配合光子照射治疗黄褐斑的临床研究

Clinical study of oral intake of tranexamic acid tablets combined with photon irradiation in treatment of chloasma

目的探讨口服氨甲环酸片配合光子照射治疗黄褐斑的临床疗效。方法我院于2008年8月1日～2012年8月1日收治的黄褐斑患者336例,给予氨甲环酸片配合光子照射治疗,随访12个月,观察临床疗效。结果58.9%的患者在治疗2周后开始出现色斑减轻,12个月后,基本治愈率为48.5%,总有效率达98.5%,治疗后3、6、9个月的基本治愈率与治疗后12个月的基本治愈率均有显著性差异(P<0.05),治疗后3、6、9个月的总有效率与治疗后12个月的总有效率均无显著性差异(P>0.05),且均无严重不良反应。结论氨甲环酸片配合光子照射治疗黄褐斑临床疗效可靠,副作用少,安全度高,值得临床推广应用。

Objective To explore the clinical efficacy of the oral intake of tranexamic acid tablets combined with photon irradiation in the treatment of chloasma. Methods 336 patients with chloasma treated in our hospital from August 1, 2008 to August 1, 2012 were given the oral intake of tranexamic acid tablets combined with photon irradiation treatment and followed up for 12 months. The clinical efficacy was observed. Results The pigmentation began to ease after two weeks of treatment in 58.9% of the patients;After 12 months,the basic cure rate was 48.5% and the total effective rate reached 98.5%. The basic cure rates after 3, 6 and 9 months of treatment were significantly different from that after 12 months of treatment （P 〈 0.05）; The total effective rates after 3, 6 and 9 months of treatment were not significantly different from that after 12 months of treatment （P 〉 0.05）; No severe adverse reaction was observed. Conclusion Oral intake of tranexamic acid tablets combined with photon irradiation has reliable clinical efficacy, few side effects and high safety in the treatment of chloasma, thereby worthy of clinical promotion and application.