咳嗽变异性哮喘与肺炎支原体感染关系的Meta分析

The association between cough variant asthma and mycoplasma infection: a meta analysis

目的探讨咳嗽变异性哮喘(CVA)的发生和肺炎支原体感染(MP)之间的关联,从而为咳嗽变异性哮喘的发病因素提供循证医学证据。方法按照统一的检索策略计算机检索PubMed、Cochorane、CNKI、万方数据库和维普数据库,搜集近10年有关咳嗽变异性哮喘与肺炎支原体感染关系的全文文献,以病例组和对照组患者血清MP-IgM滴度变化为效应指标,在全面文献回顾的基础上对文献进行筛选、评价和数据提取。应用Stata10.0软件中的Meta分析方法对各研究原始数据进行统计分析,计算合并OR值及95%CI,并进行敏感性分析和发表偏倚的估计。结果严格依照纳入标准和排除标准,共纳入文献21篇。病例组1467例患者,对照组1399例,病例组血清MP-IgM比对照组高4.32倍,95%CI为3.589～5.252。结论肺炎支原体感染患者中MP-IgM滴度的升高与咳嗽变异性哮喘发生的密切相关。

Objective To date,published data regarding the associations between the cough variant asthma（CVA） and mycoplasma（MP） infection were controversial.We aim to investigate the associations between the cough variant asthma and mycoplasma infection by conducting a Meta analysis. Methods We used PubMed,Cochorance,CNKI,Wanfang database and Weipu database to search all the relevant case-control study of full text about the associations between the CVA and MP infection and the outcomes were abstract after assessing the MP-IgM titer in the patients＇ serum. Statistical analysis was calculated by StatalO.0 software including pooled OR,95%Cl,sensitivity and publication bias. Results A total of 21 studies with 1467 cases and 1399 controls were included based on the selection criteria. The pooled OR was 4.32. The 95%CI was 3.589-5.252. Conclusion MP infection seems to be involved in the risk of the cough variant asthma.