氧化应激状态与阻塞性睡眠呼吸暂停低通气综合征的关系

The relationship of oxidative stress state and obstructive sleep apnea-hypopnea syndrome

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与患者体内氧化应激状态的相关性。方法选择我院OSAHS患者共40例,与正常对照组40例进行多导睡眠仪监测(PSG),采集各组受试者当天睡前及次日晨起空腹静脉血,检测血清中抑制羟自由基(OH.)能力、抗超氧阴离子自由基(O2ˉ)能力及谷胱甘肽(GSH)含量。结果 OSAHS组GSH含量、血清抑制OH.能力、抗O2ˉ能力均比对照组低,差异具有统计学意义(P<0.05);OS-AHS组GSH含量、血清抑制OH.能力、抗O2ˉ能力晨起比睡前降低,差异具有统计学意义(P<0.05);OSAHS组晨起血清抑制OH.能力、抗O2ˉ能力、GSH水平与AHI呈负相关,与睡眠呼吸障碍事件时最低SaO2呈正相关。结论 OSAHS与氧化应激状态存在着密切联系,OSAHS患者有持续氧化应激存在,睡眠过程可加重氧化应激状态。

Objective To investigate the relationship of oxidative stress state and obstructive sleep apnea-hypopnea syndrome. Methods A total of 40 cases of OSAHS patients were selected in our hospital, and normal control group （40 cases） with guide sleep instrument monitoring （PSG）. Collected the participants before the day and the next day in the morning fasting venous blood, the measurement of serum suppression of hydroxide radical （OH＇） ability, resist su- peroxide free radical （02-） ability and glutathione （GSH） content. Results OSAHS group of GSH content, serum inhi- bition OH＇, resistance and 02- ability were lower than the control group, with significant difference （P 〈 0.05）, OS- AHS group of GSH content, serum inhibition OH＇, resistance and 02- ability was reduced than the morning before bedtime, with significant difference （P 〈 0.05）. OSAHS group morning on serum inhibition OH-, resistance and 02- a- bility, GSH level and AHI negatively correlated with a sleep-related breathing disorder event minimum Sa02 were pos- itively correlated. Conclusion OSAHS and oxidative stress state is close contact, patients with OSAHS for oxidative stress exists, sleep process may increase the oxidative stress state.