颅脑损伤急性期C-反应蛋白与脑损伤程度、病情发展及预后的关系探讨

Correlation of C-Reactive Protein with Severity,Progression and Prognosis of Brain Injury in Acute Stage

目的探讨颅脑损伤后脑脊液及血清C-反应蛋白(CRP)与脑损伤程度、病情发展变化及预后的关系。方法颅脑损伤患者65例,按GCS评分分为轻型组15例,中型组20例,重型组30例。采集其伤后1 d内至4周的脑脊液及血清,以免疫比浊法测定脑脊液和血清中CRP的含量,并与实时的影像学资料进行比较。结果伤后7 d轻、中、重各组脑脊液及血清CRP含量比较差异有统计学意义(P<0.01);CRP的变化与影像学改变密切相关,并直观体现病情变化趋势。结论脑脊液和血清中CRP的含量是反应颅脑损伤急性期脑细胞损伤的敏感指标,对判断病情、疗效及预后有重要意义。

Objective To explore the correlation of C-reactive protein（CRP） in cerebrospinal fluid and serum with severity, progression and prognosis of brain injury in acute stage. Methods According to glasgow coma score （GCS） ,65 patients with brain injury were divided into three groups,15 patients in mild group,20 patients in moderate group ,30 patients in sever group. The cerebrospinal fluid and serum were collected from the patients in the period of one day to four weeks after they were hurt. Immunoturbidimetric assay was used to detect the level of CRP in cerebrospinal fluid and serum which was compared with the real-time imaging data. Results There was significant difference in the level of CRP detected 7 days after injury among mild group, moderate group and sever group （P 〈 0.01 ） ;The changes of CRP correlated with imaging changes, and suggested the disease trend. Conclusion The level of CRP in cerebrospinal fluid and serum is a sensitive index to reflect brain injury in acute stage,which is of great value for judging the disease＇s progression, efficacy and prognosis.