摘要
目的系统评价国内有关食管鳞癌组织中上皮钙黏素(E-cadherin)蛋白表达临床意义。方法计算机检索CBM disc、CNKI、VIP、万方数据库,并辅以文献追溯的方法,搜集国内公开发表的所有关于食管鳞癌组织中E-cadherin表达及其与临床病理特征关系的病例对照研究。按纳入、排除标准筛选文献并评价纳入研究的质量。应用RevMan 5.1.0软件进行Meta分析。结果共纳入7篇文献,食管鳞癌473例,正常食管对照423例。Meta分析结果显示,E-cadherin在食管鳞癌组与正常食管对照组[OR=0.14,95%CI(0.08,0.26)]、食管鳞癌高中分化组与低未分化组[OR=2.63,95%CI(1.52,4.56)]、食管鳞癌淋巴结转移组与无淋巴结转移组[OR=0.37,95%CI(0.24,0.56)]、食管鳞癌浅层浸润组与深肌层浸润组[OR=2.58,95%CI(1.20,5.57)]、临床Ⅰ～Ⅱ期组与临床Ⅲ～Ⅳ期组[OR=17.06,95%CI(4.20,69.22)]的表达差异均有统计学意义。结论 E-cadherin低表达或表达缺失可能在食管鳞癌的发生、发展、转移及预后中起重要作用,这对于食管鳞癌的早期诊断、治疗及预后分析具有重要的参考意义。
Objective To investigate the expression and clinical significance of E-cadherin in human esophageal squamous carcinoma. Methods The published studies were searched in the CBM disc,CNKI,VIP,and WanFang database, and other relevant journals were also hand-searched to identify all the relevant case-control trials. The quality of the included studies was assessed. The Cochrane Collaboration＇s software RevMan 5.1.0 was used to conduct a Meta-analysis. Results A total of 7 studies were recruited,including 473 cases of esophageal squamous carcinoma and 423 cases of normal controls. The Meta-analysis results showed that significant difference was found in the positive rate of E-cadherin expression between esophageal squamous carcinoma vs. normal esophageal tissues （ OR = 0. 14,95% C1：0.08 - 0.26）, cell differentiation G1 - 2 vs. cell differentiation G3- G4（ OR = 2. 63,95% CI： 1.52-4. 56）,lymph node metastasis vs. non-lymph node metastasis （OR =0.37,95%CI：0.24 -0.56） ,deep muscularis vs. superficial muscularis （OR =2.58,95% CI： 1.20 -5.57） ,clinical stages Ⅰ - Ⅱ vs. clinical stages Ⅲ- Ⅳ （ OR = 17.06,95% CI： 4.20 - 69.22）, respectively. Conclusion Reduced expression of E-cadherin may play an important role in the carcinogenesis,progression,metastasis of esophageal squamous carcinoma, which might be valuable for the early diagnosis,treatment,and prognosis of esophageal squamous carcinoma.
出处
《广西医学》
CAS
2013年第3期304-308,共5页
Guangxi Medical Journal
