小剂量红霉素对重症肺炎患儿胃食管反流的影响

Effects of Erythromycin on Gastroesophageal Reflux in Children with Severe Pneumonia

目的:了解小剂量红霉素对重症肺炎患儿胃食管反流(GER)的影响。方法:选择重症肺炎患儿25例,于鼻饲前1 h和餐后3 h连续进行食管pH监测,再给予3～5 mg/kg红霉素持续静脉滴注,同样于鼻饲前1 h和餐后3 h进行食管pH监测,比较红霉素用药前后各项反流指标的差异。结果:滴注红霉素前,重症肺炎儿童GER发生率为60.0%(15/25),滴注红霉素后,GER发生率为32.0%(8/25),用药前后比较差异有统计学意义(χ2=3.95,P<0.05)。滴注红霉素前后各项反流指标比较差异均有统计学意义(P均<0.05)。结论:重症肺炎患儿GER发病率高,小剂量红霉素静脉滴注可明显减少GER的发生。

Objective： To investigate the effects of low-dose erythromycin on gastroesophageal reflux （GER） in children with severe pneumonia. Methods： Twenty-five children with severe pneumonia were recruited to undergo intraluminal pH monitoring one hour before nasal feeding and three hours after the meal. After intake of erythromycin [ （3-5 ） mg/kg, iv ], the examination mentioned above were done in accordance with the same procedure as those before erythromycin intervention. Results： Fifteen （60.0%） of 25 children with sever pneumonia were diagnosed as GER before intake of erythromycin, while only eight were diagnosed as GER after intake of erythromycin （32.0%） （X2 =3.95, P〈0.05 ）. All parameters were significantly different between those before and after intake of erythromycin （P〈0.05）. Conclusions ： The incidence rate of GER in children with severe pneumonia is high. Administration of low- dose erythromycin significantly decreases the gastroesophageal reflux in children with severe pneumonia.