全肺切除治疗低肺功能肺结核毁损肺患者的临床研究

Clinical study of pneumonectomy in the treatment of patients with low lung function tuberculosis destroyed lung

目的探讨全肺切除治疗低肺功能肺结核毁损肺患者的临床应用价值。方法选择低肺功能肺结核毁损肺患者36例,所有患者均选择全肺切除术,其中左侧全肺切除19例,右侧全肺切除17例,术前及术后应用抗结核药物。观察患者治疗后的治愈率、肺结核转阴率、并发症发生情况及死亡率。比较患者术前、术后3、6个月肺功能情况。结果临床治愈35例,治愈率97.22%。术前痰培养阳性36例,术后痰培养阴性34例,转阴率为94.44%。术后患者肺功能逐渐改善,与术前相比,患者术后3个月及6个月FEV1、MVV水平均逐渐升高,其差异均具有统计学意义(P<0.05)。结论全肺切除在选择性低肺功能肺结核毁损肺患者的治疗中具有很高临床应用价值。

Objective To investigate the clinical value of total pneumonectomy in the treatment of patients with low lung function tuberculosis destroyed lung.Methods 36 patients with low lung function tuberculosis destroyed lung were chosen to give total pneumonectomy,which included 19 cases of whole left lung resection and 17 cases of whole right lung resection.Anti-TB drugs were used preoperatively and postoperatively.The cure rate,seroconversion rate of tuberculosis,complications and mortality were observed.Their lung function was compared before 3 and 6 months after the treatment.Results 35 patients were cured and the cure rate was 97.22%.Preoperative sputum culture was positive in 36 cases,and 34 cases turned negative after the treatment.The negative conversion rate was 94.44%.The levels of FEV1 and MVV increased gradually 3 and 6 months after the treatment with statistical significance（P0.05）.Conclusion Total pneumonectomy has a high clinical value in the treatment of patients with low lung function tuberculosis destroyed lung.