莫西沙星对慢阻肺心功能失代偿期患者QT离散度的影响

Effect of moxifloxacin on QT dispersion of cor pulmonale patients with decompensation

目的观察莫西沙星对肺心病失代偿患者QT离散度的影响。方法将60例使用莫西沙星患者分成两组,一组为肺心病失代偿患者,另一组为非肺心病失代偿患者,予以莫西沙星抗感染治疗,记录患者QT离散度并进行分析。结果 30例肺心病失代偿患者予以莫西沙星抗感染治疗,用药2小时和用药48小时分别与用药前QTd比较有显著统计学意义(P<0.05),用药2小时与用药48小时QTd比较有显著统计学意义(P<0.05);30例非肺心病失代偿患者予以莫西沙星抗感染治疗,用药2小时与用药前QTd比较无显著统计学意义(P>0.05),用药48小时与用药前QTd比较有显著统计学意义(P<0.05)。结论莫西沙星可以增加QTd的作用,尤其对有肺心病等潜在QT间期延长的患者,应警惕QTd增大延长不良反应的发生。

Objective To investigate the effect of moxifloxacin on QT dispersion of cor pulmonale patients with decompensation.Methods 60 patients were randomly divided into two groups： the decompensation group and the non-decompensation group.All patients were treated with moxifloxacin and their QT dispersion were recorded and analyzed.Results The difference of QT dispersion showed a statistical significance before and 2 and 48 hours after the treatment in the decompensation group（P0.05）.There was no significant difference before and 2-hour after the treatment in the non-decompensation group（P0.05）,but it showed statistical significance before and 48-hour after the treatment in the non-decompensation group（P0.05）.Conclusion Moxifloxacin can prolong the effect of QT dispersion,especially for those cor pulmonale patients with decompensation.The adverse reactions caused by the prolongation of QT dispersion should be paid more more attention.