布地奈德氨溴索雾化吸入治疗婴幼儿肺炎支原体感染临床疗效观察

Observation of clinical effect of budesonide combined with ambroxol atomization inhalation in the treatment of infants with chronic cough caused by pneumonia mycoplasma infection

目的分析布地奈德联合盐酸氨溴索雾化吸入治疗婴幼儿肺炎支原体感染所致慢性咳嗽的临床效果。方法选取本院儿科收治的因肺炎支原体感染所致慢性咳嗽患儿100例,按随机原则分为实验组对照组各50例,两组均给予阿奇霉素抗感染治疗,对照组给予盐酸氨溴索雾化吸入,实验组在上述治疗基础上另给予布地奈德雾化吸入。观察两组用药前后检测外周静脉血嗜酸粒细胞阳离子蛋白、嗜酸粒细胞及T-IgE水平,另记录患者症状改善时间及3月内反复发作次数。结果两组经治疗并随访3月后ECP、EOS方面与治疗前均明显降低,P<0.05,两组IgE较治疗前明显升高(P<0.05),但治疗后组间比较则无统计学差异(P>0.05),治疗组在症状缓解时间,症状消失时间及3月内复发次数明显低于对照组(P<0.05)。结论盐酸氨溴索联合布地奈德雾化吸入,治疗婴幼儿肺炎支原体感染致慢性咳嗽,疗效显著。

Objective To analyze the clinical effect of budesonide combined with ambroxol atomization inhalation in the treatment of infants with chronic cough caused by pneumonia mycoplasma infection.Methods 100 cases of chronic cough infants caused by PMI were randomly and evenly divided into the test group and the control group.Both groups were given azithromycin anti-infectious treatment and ambroxol HCL ambroxol atomization,and the test group was given budesonide ambroxol atomization additionally.ECP,EOS and T-IgE level of PB were observed before and after the treatment,and the patients′ symptoms relieve-time and relapse times within 3 months were recorded.Results 3 months follow-up after the treatment,ECP,EOS decreased obviously,and IgE increased significantly（P0.05）,but there was no significant difference between the two groups.The remission time and disappear time of symptoms and relapse times within 3 months were obviously shorter in the test group than in the control group（P0.05）.Conclusion Budesonide combined with ambroxol atomization inhalation has an obvious clinical effect in the treatment of infants with chronic cough caused by pneumonia mycoplasma infection and it is worth to be promoted widely in clinical application.