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慢性阻塞性肺疾病的自身免疫损伤机制 被引量:7

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摘要 COPD是以持续气流受限为特征并伴有广泛肺外效应的一种慢性疾病。反复急性加重和合并症加剧患者病情的整体严重程度并严重影响其预后[1]。COPD的发病机制复杂,尚未充分阐明。现有的理论认为:与有害颗粒和(或)气体相关的异常炎症反应是COPD的本质,但同样是抗炎等治疗却并不能取得像支气管哮喘那样较理想的治疗效果,
作者 陈磊 文富强
出处 《临床肺科杂志》 2013年第5期905-907,共3页 Journal of Clinical Pulmonary Medicine
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参考文献14

  • 1Global Strategy for Diagnosis, Management, and Prevention of COPD ( Updated 2011 ).
  • 2Shapiro SD. End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on[ J]. Am J Respir Crit Care Med, 2001,164:339 - 40.
  • 3Cosio MG. Autoimmunity, T-cells and STAT-4 in the pathogenesis of chronic obstructive pulmonary disease[ J ]. Eur Respir J, 2004, 24:3 - 5.
  • 4Cosio MG,Saetta M,Agusti A. Immunologic aspects of chronic ob- structive pulmonary disease[J]. N Engl J Meal,2009, 360(23) : 2445 - 54.
  • 5Brusselle GG,Joos GF,Bracke KR. New insights into the immunol- ogy of chronic obstructive pulmonary disease [ J ]. Lancet, 2011, 10, 378 (9795):1015 -26.
  • 6Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease[ J]. Nat Rev Immunol, 2006,6:823 - 35.
  • 7Demedts IK, Bracke KR, Van Pottelberge G, et al. Accumulation of dendritic ceils and increased CCL20 levels in the airways of pa- tients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2007, 175 : 998 - 1005.
  • 8Bratke K, Klug M, Bier A, et al. Function-associated surface mol- ecules on airway dendritic cells in cigarette smokers[ J]. Am J Re- spir Cell Mol Biol, 2008,38 : 655 -60.
  • 9Freeman CM, Curtis JL, Chensue SW. CC chemokine receptor 5 and CXC chemokine receptor 6 expression by lung CDs+ ceils corre- lates with chronic obstructive pulmonary disease severity[ J. Am J Pathal, 2007,171:767 - 76.
  • 10Chrysofakis G, Tzanakis N, Kyriakoy D, et al. Perforin expression and cytotoxic activity of sputum CDs+ lymphocytes in patients with COPD[J]. Chest, 2004,125:71 -6.

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