手足口病患儿血清IL-6检测及意义

Detection of serum IL-6 level in children with hand-foot-mouth disease and its significance

目的探讨血清IL-6水平检测在手足口病(HFMD)诊疗中的作用。方法采用ELISA双抗体夹心法测定72例HFMD患儿(观察组)及72例同期健康体检儿童(对照组)血清IL-6水平,并根据患儿的临床表现、实验室检查结果、病程、病情、有无并发症、肠道病毒等不同指标将HFMD患儿分组进行血清IL-6含量比较。结果观察组患儿血清IL-6水平明显高于对照组(P<0.01);病程较长的HFMD患儿血清IL-6水平明显高于病程较短的HFMD患儿(P<0.01),重症HFMD患儿血清IL-6水平明显高于轻症HFMD患儿(P<0.01),EV71阳性HFMD患儿血清IL-6水平明显高于非EV71感染的HFMD患儿,血清IL-6水平与血糖、白细胞计数分类、CRP等常规实验室检查无显著相关性(P均>0.05)。结论 IL-6与HFMD的病理生理过程密切相关,其可以作为HFMD患儿早期诊断、分型、治疗及预后判断的重要指标。

Objective To investigate the effects of detection of serum IL-6 level on the diagnosis and treatment of HFMD. Methods The serum levels of IL-6 in 72 cases of HFMD children （ observation group） and 72 cases of healthy children （control group） were measured by ELISA. The serum IL-6 content was compared in different groups of HFMD patients according to the clinical manifestations, laboratory results, course of disease, illness, with or without complications, intestinal virus and so on. Results The serum level of IL-6 in observation group was significantly higher than that in control group（P〈0.01 ）. The serum level of IL-6 in the longer course HFMD patients was significantly higher than that in short course ones（ P 〈 0.01 ）. The serum level of IL-6 in the severe HFMD cases and the general ones had significant difference（ P 〈0.01 ）. And the serum level of IL-6 in the EV71 positive HFMD patients was significantly higher than that in the non-EV71 positive ones（ P 〈 0.05 ）. There was no significant correlation between the serum level of IL-6 and routine laboratory tests, such as blood sugar, WBC count and differentiation, CRP （ P 〉 0.05 ）. Conclusions IL-6 might be closely related to the pathogenesis of HFMD. The serum level of IL-6 can be the important indicator for early diagnosis, classification, treatment and prognosis in HFMD patients.