血清MMP-9及颈动脉粥样硬化斑块稳定性与脑梗死的相关性研究

Relationship between serum MMP-9 and plaque stability of carotid atherosclerosis in patients with cerebral infraction

目的探讨脑梗死与颈动脉粥样硬化斑块稳定性及血清基质金属蛋白酶-9(MMP-9)之间的关系。方法 132例急性脑梗死患者按病史分为初发组(n=95例)与复发组(n=37例),采用彩色多普勒超声检测颈动脉内膜中层厚度(IMT)及动脉粥样硬化斑块,并按斑块性质分为稳定性斑块和不稳定斑块,同时检测血清MMP-9水平,分析组间指标差异。结果与初发组患者比较,复发组患者颈动脉粥样硬化斑块数、不稳定斑块数及MMP-9水平均明显升高(P均<0.05),而IMT两组间差异无统计学意义(P>0.05);与稳定性斑块组比较,不稳定斑块组患者MMP-9水平明显升高(P<0.01),而IMT两组间差异无统计学意义(P>0.05)。结论颈动脉粥样硬化斑块的稳定性与再发脑梗死风险密切相关,而MMP-9水平可作为反映的斑块稳定性及再发脑梗死的血清学指标。

Objective To explore the relationship between serum matrix metalloproteinases-9 （MMP-9） and plaque stability of carotid athemsclerosis in patients with cerebral infraction. Methods One hundred and thirty-two patients with cerebral infraction were divided into primary group （n=95） and recurrent group （n=37）. The carotid intima-media thickness （IMT）, athemsclemsis plaques in carotid were assessed by color Doppler ultrasound. The plaques were divided into stability group and instability group, and the level of serum MMP-9 was detected. Results The levels of serum MMP-9, the numbers of plaques and unstable-plaques of patients in primary group were both significant higher than those of patients in recurrent group, but IMT was similar between two groups. The levels of serum MMP-9 of patients in instability group were significant higher than those of patients in stability group, but IMT was similar between two groups. Conclusion Carotid atherosclerosis and plaque＇s stability are closely related to the risk of recurrent cerebral infraction, and the level of serum MMP-9 may be a potential serum maker of unstable plaque and recurrent cerebral infraction.