胃肠道肿瘤纳米靶向治疗进展

Advances in the treatment of nanoparticles targeting to gastrointestinal tumors

胃肠道肿瘤是严重危害人类健康的疾病。据统计，全世界每年因胃癌死亡人数达70万，占所有恶性肿瘤死亡人数的1／10；结直肠癌发病率在所有恶性肿瘤中排第3位，在癌症引起的死亡病例中排第4位。目前胃肠道肿瘤主要依靠手术、化疗等治疗方法，但对已经发生远端转移的肿瘤却收效甚微。近年来，由于各种纳米粒子能理想地在体内传递各种物质并具有可调的表面化学靶向结构，使得它在胃肠道肿瘤的靶向治疗中显现出独特的优势。本文就纳米材料介导的胃肠道肿瘤靶向治疗进展作一概述。

Gastrointestinal tumors are the major disease that threaten human health. According to statistics, more than 700 000 people died every year because of gastric cancer, 1/10 of all cancer mortality. Colorectal cancer incidence of malignant tumors, which ranked third , ranked fourth in cancer deaths. At now the treatment of gastrointestinal tumors mostly are operation, radiotherapy and chemotherapy, but to spread of tumors, doctors still haven＇ t more better method. Nanoparticles have properties in the diagnosis and treatment of cancer, including their sizedependent properties, stability in solvent, ideal size for delivery within the body, and tunable surface chemistry for targeted delivery. Here, the author do an overview of nanoparticles in gastrointestinal tumors ablation.