非经典抗精神病药对双相情感障碍患者代谢的影响研究

Non classical antipsychotic drugs for patients with bipolar disorder metabolism research

目的探析非经典抗精神病药用于双相情感障碍患者代谢的影响。方法将患者分为观察组与对照组,分别使用非经典抗精神病药联合心境稳定剂的治疗方式和单独使用非经典抗精神病药的治疗方式,比较治疗后代谢综合征的发生情况,以及代谢综合征相关指标的具体呈现情况。结果观察组代谢综合征的发生率为23.3%,对照组为50.0%;另外,在SBP、DBP、TG、TC、HbALc、LDL-C、HDL-C几项指标上,观察组患者整体呈现情况更佳,以上比较差异均具有显著性(P<0.05)。结论非经典抗精神药物单独使用治疗双相情感精神障碍,对患者代谢影响较大,但联合心境稳定剂使用,整体效果理想,值得临床推广。该文旨在通过回顾性该院收治的双相情感精神障碍患者临床资料,对非经典抗精神病药在治疗中对患者代谢产生的影响进行分析研究。

Objective Research on non classical antipsychotic drugs for patients with bipolar disorder metabolism. Methods The patients were divided into observation group and control group, respectively, using a classical antipsychotics combined with a mood stabilizer treatment modalities and separate use of atypical antipsychotic drugs treatment after treatment, compared the prevalence of metabolic syndrome, as well as the metabolic syndrome indices related to the specific situation. Results In the observation group, the incidence of metabolic syndrome was 23.3%, 50% in control group; in addition, the SBP, DBP, TG, TC, HbALc, LDL-C, HDL-C on several index, the patients in the observation group is better than comparison show, the difference was Significant （P〈0.05）. Conclusion Non classical antipsychotic drugs used alone in the treatment of bipolar affective disorder, on patients with metabolic impact, but combined with mood stabilizers, the overall effect is ideal, worthy of clinical application, This paper retrospectively in our hospital of bipolar affective disorder in patients with clinical data, the non classical antipsychotic drugs in the treatment of patients with metabolic impact analysis study.