巴曲酶治疗全频型突发性耳聋的疗效分析

The Effectiveness Analysis of Batroxobin in Treatment of the Wide Frequency Sudden Deafness

目的评价加用巴曲酶治疗全频型突发性耳聋的临床疗效。方法对2009年1月-2011年6月耳鼻喉一科收治的全频下降型突发性耳聋患者83例(83耳),其中39例患者采用金纳多、甲钴胺、维生素B1等常规方法治疗,而另外44例患者在常规方法基础上加用巴曲酶治疗,两组治疗前后均进行纯音听阈及相关听力检查,并进行头颅及内听道核磁检查排除内听道及颅内占位性病变后,比较两组的治疗效果。结果治疗前两组患者的年龄、听力下降程度、相关因素等差异均无统计学意义(P>0.05),治疗后加用巴曲酶治疗组总有效率为88.6%,明显优于常规治疗组的总有效率(64.1%),差异有统计学意义(P<0.05)。结论常规治疗基础上加用巴曲酶溶栓治疗可缓解血管内血栓阻塞因素,对于全频型突发性耳聋有明显疗效,值得推广。

Objective To assess the effectiveness of batroxobin on sudden sensorineural hearing loss（SSHL）.Methods 83 cases（83 ears） of the wide frequency sudden deafness were treated in my hospital from Jan 2009 to Jun 2011.39 patients were treated with routine method such as extract of Ginkgo Biloba Leaves Injection,Mecobalamin for Injection,and VitB1.Another 44 patients were treated with batroxobin and routine method.The hearing examination was performed before and after treatment for two groups cases.While head and internal auditory canal MR imaging were examined to rule out intracranial lesions.Comparing two group of effect after treatment was conducted.Results The age and the degree of hearing loss and relevant factors was not significantly different between two groups（P0.05）.The rate of group with batroxobin and routine treatment was 88.6%,which was better than rate of group with routine treatment（64.1%）.There was significant difference between them（P0.05）.Conclusion Batroxobin in treatment of the wide frequency sudden deafness was better than routine treatment.This therapy strategy can ease the intravascular thrombotic occlusion and other factors should be clinically recommended.